Journal of the Chinese Medical Association
Volume 73, Issue 6 , Pages 308-313, June 2010

Surgical Outcomes in Resected Non-small Cell Lung Cancer ≤ 1 cm in Diameter

  • Bing-Yen Wang

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Bing-Yen Wang and Jung-Jyh Hung contributed equally to this work.
    • ,
  • Jung-Jyh Hung

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Division of Thoracic Surgery, Department of Surgery, Cathay General Hospital and Fu Jen Catholic University School of Medicine, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • Bing-Yen Wang and Jung-Jyh Hung contributed equally to this work.
    • ,
  • Wen-Juei Jeng

      Affiliations

    • Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Wen-Hu Hsu

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Chih-Cheng Hsieh

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Min-Hsiung Huang

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Biing-Shiun Huang

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jung-Sen Liu

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Cathay General Hospital and Fu Jen Catholic University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Yu-Chung Wu

      Affiliations

    • Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Yu-Chung Wu, Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.

Received 25 January 2010; accepted 27 May 2010.

Article Outline

Background

The goal of this study was to investigate the prognostic factors and patterns of recurrence in patients with resected non-small cell lung cancer (NSCLC) ≤ 1 cm in diameter.

Methods

We conducted a retrospective review of the clinicopathological characteristics of 71 patients with NSCLC ≤ 1 cm in diameter in Taipei Veterans General Hospital between 1982 and 2007. Overall survival and its predictors were analyzed.

Results

Median follow-up time of the 71 patients was 33.3 months. Complete resection was performed in 68 patients (95.8%) with stage I disease. The 5- and 10-year overall survival rates of patients who underwent complete resections were 81.7% and 44.9%, respectively. There was tumor recurrence in 6 (8.8%) of these 68 patients. Five (9.3%) of 54 patients who underwent standard resection experienced tumor recurrence, but only 1 (7.1%) of 14 patients who received sublobar resection had recurrent disease. The difference was not statistically significant (p = 0.569). Multivariate analysis revealed that sublobar resection (hazard ratio, 5.00; 95% confidence interval, 1.28–20.00; p = 0.020) was a significant predictor for worse overall survival.

Conclusion

Survival in patients with NSCLC £ 1 cm in diameter is satisfactory. Sublobar resection, performed in patients unfit for standard resection, is a poor prognostic factor for overall survival.

Key Words:  non-small cell lung cancer , predictor , subcentimeter , sublobar resection , survival

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PII: S1726-4901(10)70066-6

doi:10.1016/S1726-4901(10)70066-6

Journal of the Chinese Medical Association
Volume 73, Issue 6 , Pages 308-313, June 2010

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