Surgical Outcomes in Resected Non-small Cell Lung Cancer ≤ 1 cm in Diameter
Received 25 January 2010; accepted 27 May 2010.
Background
The goal of this study was to investigate the prognostic factors and patterns of recurrence in patients with resected non-small cell lung cancer (NSCLC) ≤ 1 cm in diameter.
Methods
We conducted a retrospective review of the clinicopathological characteristics of 71 patients with NSCLC ≤ 1 cm in diameter in Taipei Veterans General Hospital between 1982 and 2007. Overall survival and its predictors were analyzed.
Results
Median follow-up time of the 71 patients was 33.3 months. Complete resection was performed in 68 patients (95.8%) with stage I disease. The 5- and 10-year overall survival rates of patients who underwent complete resections were 81.7% and 44.9%, respectively. There was tumor recurrence in 6 (8.8%) of these 68 patients. Five (9.3%) of 54 patients who underwent standard resection experienced tumor recurrence, but only 1 (7.1%) of 14 patients who received sublobar resection had recurrent disease. The difference was not statistically significant (p = 0.569). Multivariate analysis revealed that sublobar resection (hazard ratio, 5.00; 95% confidence interval, 1.28–20.00; p = 0.020) was a significant predictor for worse overall survival.
Conclusion
Survival in patients with NSCLC £ 1 cm in diameter is satisfactory. Sublobar resection, performed in patients unfit for standard resection, is a poor prognostic factor for overall survival.
No full text is available. To read the body of this article, please view the PDF online.
aDivision of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
bDivision of Thoracic Surgery, Department of Surgery, Cathay General Hospital and Fu Jen Catholic University School of Medicine, Taipei, Taiwan, R.O.C.
cInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
dDepartment of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan, R.O.C.
Correspondence to: Dr Yu-Chung Wu, Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
† Bing-Yen Wang and Jung-Jyh Hung contributed equally to this work.
ABSTRACT