Volume 73, Issue 6, Pages 281-288 (June 2010)

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ABSTRACT

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Advances in Combination of Antiangiogenic Agents Targeting VEGF-binding and Conventional Chemotherapy and Radiation for Cancer Treatment

Received 30 November 2009; accepted 14 April 2010.

Despite great efforts and resources being devoted to treatment, the incidence and mortality of numerous cancers have not decreased in recent decades. This is a result of the resistance of cancer cells to chemotherapeutic agents and radio-therapy. The development of antiangiogenic agents that target vascular endothelial growth factor (VEGF) provides a new option for treatment of cancer. Major advances have been achieved with cancer therapy based on antiangiogenic VEGF-targeted agents in the past few years, and some of the recently approved therapies are now being used in daily clinical practice. A further challenge is finding a more efficacious combination of antiangiogenic VEGF-targeted therapies and conventional radio- and chemotherapies. This review outlines the current preclinical and clinical cancer treatments using optimized combinations of antiangiogenic VEGF-targeted agents and conventional radiochemotherapy and highlights that better scheduling for the combination of radiochemotherapy and antiangiogenic VEGF-targeted agents should be developed to achieve better treatment outcomes.

Key Words: antiangiogenic agents , bevacizumab , VEGF-targeted agents , VEGF-Trap

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References

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a Department of Surgical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang

b Department of Surgery, Zhuji Hospital, Zhuji

c Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University: Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang

d Chengdu Kanghong Biotechnology Co. Inc., Chengdu, Sichuan, China

Correspondence to: Dr Li-Song Teng, Department of Surgical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79, Qingchun Road, Hangzhou, Zhejiang 310003, China

PII: S1726-4901(10)70062-9

doi:10.1016/S1726-4901(10)70062-9

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