Journal of the Chinese Medical Association
Volume 73, Issue 3 , Pages 166-172, March 2010

Locally Advanced Oncocytic Carcinoma of the Nasal Cavity Treated With Surgery and Intensity-modulated Radiotherapy

  • Yu-Wen Hu

      Affiliations

    • Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Ching-Zong Lin

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • West Garden Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Wing-Yin Li

      Affiliations

    • Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Cheng-Pei Chang

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Ling-Wei Wang

      Affiliations

    • Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Ling-Wei Wang, Cancer Center, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.

Received 22 June 2009; accepted 11 December 2009.

Article Outline

Oncocytic carcinomas of the nasal cavity are extremely rare. We report 1 patient whose primary tumor and neck lymphadenopathies were under control nearly 2 years after combined surgery and radiotherapy. An 80-year-old man with a history of nasal oncocytoma had received excision twice previously. Computed tomography demonstrated locally advanced recurrent tumor invading the paranasal sinuses and orbit with lymphadenopathies in the right neck. Skull base surgery was performed. Pathological examination revealed oncocytic carcinoma. Positron emission tomography showed hypermetabolic lesions in the surgical bed and right neck. The patient subsequently received intensity-modulated radiotherapy to the primary site and the whole neck. Follow-up computed tomography 4 months later showed marked shrinkage of the neck lymphadenopathies. There was no progression after nearly 2 years. Although these tumors have historically been regarded as radioresistant, the combined treatment of surgery followed by radiotherapy may offer the best chance for control of locally advanced disease.

Key Words:  intensity-modulated radiotherapy , nasal cavity , oncocytic carcinoma , positron emission tomography , surgery

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PII: S1726-4901(10)70033-2

doi:10.1016/S1726-4901(10)70033-2

Journal of the Chinese Medical Association
Volume 73, Issue 3 , Pages 166-172, March 2010

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