Journal of the Chinese Medical Association
Volume 73, Issue 3 , Pages 161-165 , March 2010

Systemic Amyloidosis Manifesting as a Rare Cause of Hepatic Failure

  • Hung-Hsu Hung

      Affiliations

    • Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • De-Feng Huang

      Affiliations

    • Division of Allergy-Immunology-Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Cheng-Hwai Tzeng

      Affiliations

    • Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Cheng-Hsi Su

      Affiliations

    • Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Tung-Ping Su

      Affiliations

    • Division of General Psychiatry, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Hung-Chieh Chen

      Affiliations

    • Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shyh-Haw Tsay

      Affiliations

    • Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Han-Chieh Lin

      Affiliations

    • Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jaw-Ching Wu

      Affiliations

    • Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shou-Dong Lee

      Affiliations

    • Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Chien-Wei Su

      Affiliations

    • Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Chien-Wei Su, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.

Received 1 July 2009 ,Accepted 16 December 2009.

References 

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  2. Westermark P, Benson MD, Buxbaum JN, Cohen AS, Frangione B, Ikeda S, et al  Amyloid fibril protein nomenclature—2002 . Amyloid . 2002;9:197–200
  3. Merlini G , Bellotti V . Molecular mechanisms of amyloidosis . N Engl J Med . 2003;349:583–596
  4. Ebert EC , Nagar M . Gastrointestinal manifestations of amyloidosis . Am J Gastroenterol . 2008;103:776–787
  5. Kim SH, Han JK, Lee KH, Won HJ, Kim KW, Kim JS, et al  Abdominal amyloidosis: spectrum of radiological findings . Clin Radiol . 2003;58:610–620
  6. Kyle RA , Bayrd ED . Amyloidosis: review of 236 cases . Medicine (Baltimore) . 1975;54:271–299
  7. Levine RA . Amyloid disease of the liver: correlation of clinical, functional and morphologic features in forty-seven patients . Am J Med . 1962;33:349–357
  8. Iwata T, Hoshii Y, Kawano H, Gondo T, Takahashi M, Ishihara T, et al  Hepatic amyloidosis in Japan: histological and morphometric analysis based on amyloid proteins . Hum Pathol . 1995;26:1148–1153
  9. Brandt K , Cathcart ES , Cohen AS . A clinical analysis of the course and prognosis of forty-two patients with amyloidosis . Am J Med . 1968;44:955–969
  10. Gertz MA , Kyle RA , Greipp PR . Hyposplenism in primary systemic amyloidosis . Ann Intern Med . 1983;98:475–477
  11. Pettersson T , Konttinen YT , Maury CP . Treatment strategies for amyloid A amyloidosis . Expert Opin Pharmacother . 2008;9:2117–2128
  12. Srkalovic G , Cameron MG , Deitcher SR , Kattke-Marchant K , Hussein MA . Incidence and risk factors of venous thromboembolism (VTD) in patients with amyloidosis . Int Semin Surg Oncol . 2005;2:17
  13. Lachmann HJ, Goodman HJ, Gilbertson JA, Gallimore JR, Sabin CA, Gillmore JD, et al. Natural history and outcome in systemic AA amyloidosis . N Engl J Med . 2007;356:2361–2371

PII: S1726-4901(10)70032-0

doi: 10.1016/S1726-4901(10)70032-0

Journal of the Chinese Medical Association
Volume 73, Issue 3 , Pages 161-165 , March 2010

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