Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 35-39 , January 2010

Macroenzyme Creatine Kinase in the Era of Modern Laboratory Medicine

  • Chun-Yu Liu

      Affiliations

    • Division of Hematology and Oncology, I-Lan, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, I-Lan, Taiwan, R.O.C.
  • ,
  • Yi-Chun Lai

      Affiliations

    • Department of Medicine, I-Lan, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, I-Lan, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University Hospital, I-Lan, Taiwan, R.O.C.
  • ,
  • Yi-Chi Wu

      Affiliations

    • Section of Biochemistry, Department of Laboratory Medicine and Pathology, Taipei Veterans General Hospital, I-Lan, Taiwan, R.O.C.
  • ,
  • Cheng-Hwai Tzeng

      Affiliations

    • Division of Hematology and Oncology, I-Lan, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, I-Lan, Taiwan, R.O.C.
  • ,
  • Shou-Dong Lee

      Affiliations

    • Division of Gastroenterology, I-Lan, Taiwan, R.O.C.
    • Department of Medicine, I-Lan, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, I-Lan, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Shou-Dong Lee, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.

Received 16 June 2009 ,Accepted 11 September 2009.

References 

  1. Saenger AK , Jaffe AS . Requiem for a heavyweight: the demise of creatine kinase-MB . Circulation . 2008;118:2200–2206
  2. Robinson DJ , Christenson RH . Creatine kinase and its CKMB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction . J Emerg Med . 1999;17:95–104
  3. Wang HC , Lu JY , Ting YM . Elevated serum CK-MB and CKBB isoenzymes in a patient with small cell lung cancer: a case report . J Chin Med Assoc . 1995;55:270–273
  4. Galasso PJ , Litin SC , O'Brien JF . The macroenzymes: a clinical review . Mayo Clin Proc . 1993;68:349–354
  5. Sturk A , Sanders GT . Macro enzymes: prevalence, composition, detection and clinical relevance . J Clin Chem Clin Biochem . 1990;28:65–81
  6. Remaley AT , Wilding P . Macroenzymes: biochemical characterization, clinical significance, and laboratory detection . Clin Chem . 1989;35:2261–2270
  7. Mifflin TE, Bruns DE, Wrotnoski U, MacMillan RH, Stallings RG, Felder RA, et al. University of Virginia case conference. Macroamylase, macro creatine kinase, and other macroenzymes . Clin Chem . 1985;31:1743–1748
  8. Lee KN , Csako G , Bernhardt P , Elin RJ . Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data . Clin Chem . 1994;40(7 Pt 1):1278–1283
  9. Grace AM , Perryman MB , Roberts R . Purification and characterization of human mitochondrial creatine kinase. A single enzyme form . J Biol Chem . 1983;258:15346–15354
  10. Lang H , Wurzburg U . Creatine kinase, an enzyme of many forms . Clin Chem . 1982;28:1439–1447
  11. Morrow DA, Cannon CP, Jesse RL, Newby LK, Ravkilde J, Storrow AB, et al  National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes . Clin Chem . 2007;53:552–574
  12. Wu CJ, Liang HL, Chiou KR, Mar GY, Tseng SJ, Lin SL, et al  Significance of cardiac troponin I and creatine kinase release after coronary intervention . J Chin Med Assoc . 2001;64:343–350
  13. Loshon CA , McComb RB , Bowers GN . Immunoprecipitation and electrophoresis used to demonstrate and evaluate interference by CK-BB and atypical-CKs with CK-MB determinations by immunoinhibition . Clin Chem . 1984;30:167–168
  14. Bohner J , Stein W , Steinhart R , Wurzburg U , Eggstein M . Macro creatine kinases: results of isoenzyme electrophoresis and differentiation of the immunoglobulin-bound type by radioassay . Clin Chem . 1982;28(4 Pt 1):618–623
  15. Bohner J , Stein W , Renn W , Steinhart R , Eggstein M . Stability of macro creatine kinases and creatine kinase isoenzymes compared: heat inactivation test for determination of thermostable creatine kinases . J Clin Chem Clin Biochem . 1981;19:1021–1026
  16. Stein W , Bohner J , Steinhart R , Eggstein M . Macro creatine kinase: determination and differentiation of two types by their activation energies . Clin Chem . 1982;28:19–24
  17. Galarraga B , Sinclair D , Fahie-Wilson MN , McCrae FC , Hull RG , Ledingham JM . A rare but important cause for a raised serum creatine kinase concentration: two case reports and a literature review . Rheumatology (Oxford) . 2003;42:186–188
  18. Jap TS , Wu YC , Ho DM , Chiang H . Spuriously high CK-MB isoenzyme activity mimicking acute myocardial infarction in a patient with adenocarcinoma of the rectum . J Chin Med Assoc . 2000;63:413–417
  19. Laureys M, Sion JP, Slabbynck H, Steenssens L, Cobbaert C, Derde MP, et al. Macromolecular creatine kinase type 1: a serum marker associated with disease . Clin Chem . 1991;37:430–434
  20. Hsiao JF , Ning HC , Gu PW , Lin WY , Chu PH . Clinical role of recurrently elevated macro creatine kinase type 1 . J Clin Lab Anal . 2008;22:186–191
  21. Gallucci F , Madrid E , Esposito P , Uomo G . Association of macroamylasemia and type I macro-creatine kinasemia. A case report . JOP . 2007;8:605–608
  22. Pascarella F , Caropreso M , Miele E , Fortunato G , Vajro P , Staiano A . Macro-creatine kinase and macro-lactate dehydrogenase in a girl with ulcerative colitis . Dig Liver Dis . 2007;39:780–781
  23. Stein W , Bohner J , Renn W , Maulbetsch R . Macro creatine kinase type 2: results of a prospective study in hospitalized patients . Clin Chem . 1985;31:1959–1964
  24. Stein W , Bohner J , Bahlinger M . Analytical patterns and biochemical properties of macro creatine kinase type 2 . Clin Chem . 1985;31:1952–1958
  25. Grobbel MA , Lawson NS , Calam RR . Cathodal creatine kinase band, a poor prognostic sign in malignancy . Clin Chem . 1982;28:1995–1996

PII: S1726-4901(10)70019-8

doi: 10.1016/S1726-4901(10)70019-8

Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 35-39 , January 2010