Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 15-20 , January 2010

Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

  • Pei-Chen Tsao

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Shu-Jen Chen

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Shu-Jen Chen, Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
    • ,
  • Chia-Feng Yang

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Yu-Sheng Lee

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Mei-Jy Jeng

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Wen-Jue Soong

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Pi-Chang Lee

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jen-Her Lu

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Betau Hwang

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Ren-Bin Tang

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.

Received 7 October 2009 ,Accepted 24 November 2009.

References 

  1. Clyman RI . Patent ductus arteriosus in premature infant . In:  Taeusch WH ,  Ballard RA editor. Avery's Diseases of the Newborn . 8th edition. Philadelphia: WB Saunders; 2004;p. 816–823
  2. Narayanan M , Clyman R . Pharmacologic closure of patent ductus arteriosus in the neonate . NeoReviews . 2003;4:e215–e222
  3. Gerysony WM , Peckham GJ , Ellison RC , Miettinen OS , Nadas AS . Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study . J Pediatr . 1983;102:895–905
  4. Rudd P , Motanez P , Hallidie-Smith K , Silverman M . Indomethacin treatment for patent ductus arteriosus in very low birth-weight infants: double blind trial . Arch Dis Child . 1983;58:267–270
  5. Cooke RW , Pickering D . Poor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants . Br Heart J . 1974;41:301–303
  6. Sharma PK , Garg SK , Narang A . A preliminary study on pharmacokinetics of oral indomethacin in premature infants in north India . Indian J Med Res . 2003;117:164–169
  7. Mrongovius R , Imbeck H , Wille L , Muller H , Seyberth HW . Variability of serum indomethacin concentrations after oral and intravenous administration to preterm infants . Eur J Pediatr . 1982;138:151–153
  8. Scanlon JW . Oral aqueous suspension of indomethacin should be abandoned . Pediatrics . 1982;69:507
  9. Lewis IG , Harvey DP , Maxwell GM . Indomethacin therapy of patent ductus in preterm infants controlled by plasma levels . Aust Paediatr J . 1985;21:181–183
  10. Stevenson DK, Wright LL, Lemons JA, Oh W, Korones SB, Papile LA, et al  Very-low-birthweight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994 . Am J Obstet Gynecol . 1988;2:328–336
  11. Bhat R, Vidyasagar D, Fisher E, Hastreiter A, Ramirez JL, Burns L, et al. Pharmacokinetics of oral and intravenous indomethacin in preterm infants . Dev Pharmacol Ther . 1980;1:101–110
  12. Evans M , Bhat R , Vidyasagar D , Patel M , Hastreiter A . A comparison of oral and intravenous indomethacin disposition in the premature infant with patent ductus arteriosus . Pediatr Pharmacol . 1981;1:251–258
  13. So LY , Fok TF , Sung RY , Ho JK . Preterm infants with patent ductus arterious: treatment with an enteral preparation of indomethacin . Trop Paediatr . 1992;12:403–408
  14. Al-Za'abi MA , Donovan T , Tudehope D , Woodgate P , Collie L , Charles B . Orogastric and intravenous indomethacin administration to very premature neonates with patent ductus arteriosus: population pharmacokinetics, absolute bioavailability, and treatment outcome . Ther Drug Monit . 2007;29:807–814
  15. Alpert BS, Lewins MJ, Rowland DW, Grant MJ, Olley PM, Soldin SJ, et al  Plasma indomethacin levels in preterm newborn infants with symptomatic patent ductus arteriosus– clinical and echocardiographic assessment of response . J Pediatr . 1979;95:578–582
  16. Brash AR , Hickey DE , Graham TP , Stahlman MT , Oates JA , Cotton RB . Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus . N Engl J Med . 1981;305:67–72
  17. Petersen S , Christensen NG , Jensen KM , Ryssing E . Serum indomethacin concentrations after intravenous administration to preterm infants with patent ductus arteriosus . Acta Paediatr Scand . 1981;70:729–733
  18. Clyman RI , Chorne N . Patent ductus arteriosus: evidence for and against treatment . J Pediatr . 2007;150:216–219
  19. Cotton RB , Stahlman MT , Bender HW , Graham TP , Catterton WZ , Kovar I . Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants . J Pediatr . 1978;93:647–651
  20. Kabra NS , Schmidt B , Roberts RS , Doyle LW , Papile L , Fanaroff A . Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms . J Pediatr . 2007;150:229–234
  21. Keller RL , Clyman RI . Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus . Pediatrics . 2003;112:583–587
  22. Sangem M , Asthana S , Amin S . Multiple courses of indomethacin and neonatal outcomes in premature infants . Pediatr Cardiol . 2008;29:878–884
  23. Amin SB , Handley C , Carter-Pokras O . Indomethacin use for the management of patent ductus arteriosus in preterms: a web-based survey of practice attitudes among neonatal fellowship program directors in the United States . Pediatr Cardiol . 2007;28:193–200

PII: S1726-4901(10)70016-2

doi: 10.1016/S1726-4901(10)70016-2

Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 15-20 , January 2010

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