Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 15-20, January 2010

Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

  • Pei-Chen Tsao

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Shu-Jen Chen

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Shu-Jen Chen, Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
    • ,
  • Chia-Feng Yang

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Yu-Sheng Lee

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Mei-Jy Jeng

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Wen-Jue Soong

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Pi-Chang Lee

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jen-Her Lu

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Betau Hwang

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Ren-Bin Tang

      Affiliations

    • Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.

Received 7 October 2009; accepted 24 November 2009.

Background

The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes.

Methods

Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes.

Results

Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups.

Conclusion

Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.

Key Words:  enteral route , indomethacin , patent ductus arteriosus , preterm

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PII: S1726-4901(10)70016-2

doi:10.1016/S1726-4901(10)70016-2

Journal of the Chinese Medical Association
Volume 73, Issue 1 , Pages 15-20, January 2010

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