Invasive Adenocarcinoma of the Prostate With Urethral Tumor
Received 25 May 2009; accepted 12 November 2009.
Metastases of prostate cancer to the penis and urethra are rare and often represent advanced disease. We describe a case of newly diagnosed prostatic adenocarcinoma with metastases to the corpus spongiosum, cavernosum, and the anterior urethra. A male patient, 77 years of age, initially had lower urinary tract obstruction symptoms. His prostate-specific antigen level was 5.02 ng/mL. Digital rectal examination disclosed stony hard tumors at both lobes of the prostate. Transrectal ultrasound-guided biopsy of the prostate revealed adenocarcinoma over both lobes; the Gleason score was 4 + 4 = 8. Cystoscopy showed a penile urethral tumor and biopsy disclosed metastatic adenocarcinoma of the prostate; the Gleason score was 4 + 4 = 8. The patient initially received hormone therapy. Biochemical failure developed after 15 months and rapidly progressed to a hormone-refractory stage. Docetaxel was then prescribed. The patient died in the 25th month after the diagnosis.
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aDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
bDepartment of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
cDepartment of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
dInstitute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan, R.O.C.
Correspondence to: Dr Jian-Ri Li, Division of Urology, Department of Surgery, Taichung Veterans General Hospital, 160, Section 3, Taichung-Kang Road, Taichung 407, Taiwan. R.O.C.
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