Journal of the Chinese Medical Association
Volume 73, Issue 2 , Pages 101-103, February 2010

Invasive Adenocarcinoma of the Prostate With Urethral Tumor

  • Chi-Feng Hung

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chen-Hui Lee

      Affiliations

    • Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Siu-Wan Hung

      Affiliations

    • Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Kun-Yuan Chiu

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chen-Li Cheng

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chi-Rei Yang

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chun-Jung Chen

      Affiliations

    • Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan, R.O.C.
    • ,
  • Jian-Ri Li

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
    • Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Jian-Ri Li, Division of Urology, Department of Surgery, Taichung Veterans General Hospital, 160, Section 3, Taichung-Kang Road, Taichung 407, Taiwan. R.O.C.

Received 25 May 2009; accepted 12 November 2009.

Metastases of prostate cancer to the penis and urethra are rare and often represent advanced disease. We describe a case of newly diagnosed prostatic adenocarcinoma with metastases to the corpus spongiosum, cavernosum, and the anterior urethra. A male patient, 77 years of age, initially had lower urinary tract obstruction symptoms. His prostate-specific antigen level was 5.02 ng/mL. Digital rectal examination disclosed stony hard tumors at both lobes of the prostate. Transrectal ultrasound-guided biopsy of the prostate revealed adenocarcinoma over both lobes; the Gleason score was 4 + 4 = 8. Cystoscopy showed a penile urethral tumor and biopsy disclosed metastatic adenocarcinoma of the prostate; the Gleason score was 4 + 4 = 8. The patient initially received hormone therapy. Biochemical failure developed after 15 months and rapidly progressed to a hormone-refractory stage. Docetaxel was then prescribed. The patient died in the 25th month after the diagnosis.

Key Words:  anterior urethra , corpus cavernosum , corpus spongiosum , metastasis , prostate cancer

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PII: S1726-4901(10)70010-1

doi:10.1016/S1726-4901(10)70010-1

Journal of the Chinese Medical Association
Volume 73, Issue 2 , Pages 101-103, February 2010

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