Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 542-546 , October 2009

Extramammary Paget's Disease of the Scrotum Associated with Hepatocellular Carcinoma

  • Yu-Ching Li

      Affiliations

    • Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Lieng-Yi Lu

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Ya-Tang Yang

      Affiliations

    • Department of Pathology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chen-Chu Chang

      Affiliations

    • Department of Radiology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Li-Mien Chen

      Affiliations

    • Division of Hematology/Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Li-Mien Chen, Division of Hematology/Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, 348, Section 2, Chung-Shan Road, Taiping, Taichung 411, Taiwan, R.O.C.

Received 5 March 2009 ,Accepted 10 July 2009.

References 

  1. Fardal RW , Kierland RR , Clagett OT , Woolner LB . Prognosis in cutaneous Paget's disease . Postgrad Med . 1964;36:584–593
  2. Chanda JJ . Extramammary Paget's disease: prognosis and relationship to internal malignancy . J Am Acad Dermatol . 1985;13:1009–1014
  3. Lai YL , Yang WG , Tsay PK , Swei H , Chuang SS , Wen CJ . Penoscrotal extramammary Paget's disease: a review of 33 cases in a 20-year experience . Plast Reconstr Surg . 2003;112:1017–1023
  4. Yang WJ, Kim DS, Im YJ, Cho KS, Rha KH, Cho NH, et al. Extramammary Paget's disease of penis and scrotum . Urol . 2005;65:972–975
  5. Saitou Y, Shiraki K, Yamaguchi Y, Yamamoto N, Kawakita T, Okano H, et al  Hepatocellular carcinoma associated with extramammary Paget disease . J Clin Gastroenterol . 2004;38:89–90
  6. McCarter MD , Quan SH , Busam K , Paty PP , Wong D , Guillem JG . Long-term outcome of perianal Paget's disease . Dis Colon Rectum . 2003;46:612–616
  7. Salamanca J , Benito A , Garcia-Penalver C , Azorin D , Ballestin C , Rodriquez-Perolto JL . Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature . J Cutan Pathol . 2004;31:341–345
  8. Paget J . On disease of the mammary areola preceding cancer of the mammary gland . St Bartholemew Hosp Res Lond . 1874;10:87–89
  9. Crocker HR . Paget's disease affecting the scrotum and penis . Trans Pathol Soc Lond . 1888–1889;40:187–191
  10. Hart WR , Millman JB . Progression of intraepithelial Paget's disease of the vulva to invasive carcinoma . Cancer . 1977;40:2333–2337
  11. Curtin JP , Rubin SC , Jones WB , Hoskins WJ , Lewis JL . Paget's disease of the vulva . Gynecol Oncol . 1990;39:374–377
  12. Beck DE , Fazio VW . Perianal Paget's disease . Dis Colon Rectum . 1987;30:263–266
  13. Wada H , Urabe H . Surgical treatment of genital Paget's disease in men . Ann Plast Surg . 1984;13:199–204
  14. Nakano S , Narita R , Tabaru A , Oqami Y , Otsuki M . Bile duct cancer associated with extramammary Paget's disease . Am J Gastroenterol . 1995;90:507–508
  15. Ordonez NG , Awalt H , Mackay B . Mammary and extramammary Paget's disease: an immunohistochemical and ultrastructural study . Cancer . 1987;59:1173–1183
  16. Chang YT , Liu HN , Wong CK . Extramammary Paget's disease: a report of 22 cases in Chinese males . J Dermatol . 1996;23:320–324
  17. Urabe A , Matsukuma A , Shimizu N , Nishimura M , Wada H , Hori Y . Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma . J Cutan Pathol . 1990;17:257–265
  18. Choi YD , Cho NH , Park YS , Cho SH , Lee G , Park H . Lymphovascular and marginal invasion as useful prognostic indicators and the role of c-erbB-2 in patients with male extramammary Paget's disease: a study of 31 patients . J Urol . 2005;174:561–565
  19. Chiu TW , Wong PSY , Ahmed K , Lam SC , Ying SY , Burd A . Extramammary Paget's disease in Chinese males: a 21-year experience . World J Surg . 2007;31:1941–1946
  20. Teramoto T , Satonaka K , Kitazawa S , Fujimori T , Hayashi K , Maeda S . p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis . Cancer Res . 1994;54:231–235
  21. Bréchot C . Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms . Gastroenterology . 2004;127:56–61
  22. Sheu JC, Sung JL, Chen DS, Yang PM, Lai MY, Lee CS, et al  Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications . Gastroenterology . 1985;89:259–266
  23. Fanning J , Lambert HC , Hale TM , Morris PC , Schuerch C . Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision . Am J Obstet Gynecol . 1999;180:24–27
  24. Zollo JD , Zeitouni NC . The Roswell Park Cancer Institute experience with extramammary Paget's disease . Br J Dermatol . 2000;142:59–65
  25. Hendi A , Brodland DG , Zitelli JA . Extramammary Paget's disease: surgical treatment with Mohs' micrographic surgery . J Am Acad Dermatol . 2004;51:767–773
  26. Hatta N , Yamada M , Hirano T , Fujimoto A , Morita R . Extramammary Paget's disease: treatment, prognostic factors and outcome in 76 patients . Br J Dermatol . 2008;158:313–318

PII: S1726-4901(09)70425-3

doi: 10.1016/S1726-4901(09)70425-3

Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 542-546 , October 2009

Article Tools