Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 542-546, October 2009

Extramammary Paget's Disease of the Scrotum Associated with Hepatocellular Carcinoma

  • Yu-Ching Li

      Affiliations

    • Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Lieng-Yi Lu

      Affiliations

    • Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Ya-Tang Yang

      Affiliations

    • Department of Pathology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Chen-Chu Chang

      Affiliations

    • Department of Radiology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • ,
  • Li-Mien Chen

      Affiliations

    • Division of Hematology/Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Li-Mien Chen, Division of Hematology/Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, 348, Section 2, Chung-Shan Road, Taiping, Taichung 411, Taiwan, R.O.C.

Received 5 March 2009; accepted 10 July 2009.

Article Outline

Extramammary Paget's disease (EMPD) is a rare cutaneous carcinoma of epidermal origin. The diagnosis is frequently delayed, and the disease tends to be associated with an underlying adnexal or internal malignancy. There have been several reports of EMPD associated with carcinoma of the bladder, prostate, kidney, and colon. The association of hepato-cellular carcinoma (HCC) with EMPD appears to be exceedingly rare; to our knowledge, it has been reported only once in the English literature. Herein, we report an unusual case of EMPD of the scrotum associated with HCC. EMPD was diagnosed 1 year after the appearance of an erythematous plaque, and HCC was noted 19 months after the diagnosis of EMPD. From our experience and literature review, in patients with nonspecific skin lesions that are unresponsive to conventional treatment, EMPD should be considered and skin biopsy performed. Long-term follow-up is needed to watch for the appearance of adnexal carcinoma or internal malignancy. [J Chin Med Assoc 2009;72(10):542–546]

Key Words:  extramammary Paget's disease , hepatocellular carcinoma , scrotum

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PII: S1726-4901(09)70425-3

doi:10.1016/S1726-4901(09)70425-3

Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 542-546, October 2009

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