Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 509-514 , October 2009

Dexamethasone Inhibits Tumor Necrosis Factor-α-stimulated Gastric Epithelial Cell Migration

  • Jiing-Chyuan Luo

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Jiing-Chyuan Luo, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
  • ,
  • Chi-Hin Cho

      Affiliations

    • Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
  • ,
  • Ka-Man Ng

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
  • ,
  • Kuo-Wei Hsiang

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
  • ,
  • Ching-Liang Lu

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Tseng-Shing Chen

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Full-Young Chang

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Han-Chieh Lin

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Chin-Lin Perng

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Shou-Dong Lee

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Received 20 May 2009 ,Accepted 7 September 2009.

References 

  1. Luo JC, Shin VY, Liu ESL, So WHL, Ye YN, Chang FY, et al. Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats . J Pharmacol Exp Ther . 2003;307:692–698
  2. Yoo J , Lotz MM , Matthews JB . Cytokines in restitution . In:  Cho CH ,  Wang JY editor. Gastrointestinal Mucosal Repair and Experimental Therapeutics . 1st edition. Basel: Karger; 2002;p. 14–28
  3. Silen W , Ito S . Mechanisms for rapid re-epithelialization of gastric mucosal surface . Annu Rev Physiol . 1985;47:217–229
  4. Luo JC, Shin VY, Liu ESL, Ye YN, Wu WKK, So WHL, et al  Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs . Eur J Pharmacol . 2004;485:275–281
  5. Szabo S , Khomenko T , Gombos Z , Deng XM , Jadus MR , Yoshida M . Review article: transcription factors and growth factors in ulcer healing . Aliment Pharmacol Ther . 2000;14(Suppl):33–43
  6. Tarnawski A , Szabo IL , Husain SS , Soreghan B . Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways . J Physio Paris . 2001;95:337–344
  7. Tarnawski AS . Cellular and molecular mechanisms of gastrointestinal ulcer healing . Dig Dis Sci . 2005;50(Suppl):S24–S33
  8. Basson MD , Modlin IM , Madri JA . Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor . J Clin Invest . 1992;90:15–23
  9. Martin P . Wound healing—;aiming for perfect skin regeneration . Science . 1997;276:75–81
  10. Pai R , Szabo IL , Giap AQ , Kawanaka H , Tarnawski AS . Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signal . Life Sci . 2001;69:3055–3071
  11. Takahashi S , Shigeta JI , Inoue H , Tanabe T , Okabe S . Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats . Am J Physiol Gastrointest Liver Physiol . 1998;275:G1137–G1145
  12. Takahashi M, Ota S, Hata Y, Mikami Y, Azuma N, Nakamura T, et al  Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach . J Clin Invest . 1996;98:2604–2611
  13. Luo JC, Shin VY, Yang YH, Wu WKK, Ye YN, So WHL, et al  Tumor necrosis factor-α stimulates gastric epithelial cell proliferation . Am J Physiol Gastrointest Liver Physiol . 2005;288:G32–G38
  14. Kobayashi I, Kawano S, Tsuji S, Matsui H, Nakama A, Sawaoka H, et al  RGM1, a cell line derived from normal gastric mucosa of rat . In Vitro Cell Dev Biol Animal . 1996;32:259–261
  15. Luo JC, Lin HY, Lu CL, Wang LY, Chang FY, Lin HC, et al  Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation . Biochem Pharmacol . 2008;76:841–849
  16. Shin VY , Liu ESL , Koo MWL , Luo JC , So WHL , Cho CH . Nicotine suppresses gastric wound repair via the inhibition of polyamine and K+ channel expression . Eur J Pharmacol . 2002;444:115–121
  17. Netzer P, Halter F, Ma TY, Hoa N, Nguyen N, Nakamura T, et al. Interactions of hepatocyte growth factor and non-steroidal anti-inflammatory frogs during gastric epithelial wound healing . Digestion . 2003;67:118–128
  18. Ng KM, Cho CH, Chang FY, Luo JC, Lin HC, Lin HY, et al  Omeprazole promotes gastric epithelial cell migration . J Pharm Pharmacol . 2008;60:655–660
  19. Horie-Sakata K , Shimada T , Hiraishi H , Terano A . Role of cyclooxygenase-2 in hepatocyte growth factor-mediated gastric epithelial restitution . J Clin Gastroenterol . 1998;27(Suppl):S40–S60
  20. Loew D , Schuster O , Graul EH . Dose-dependent pharmacokinetics of dexamethasone . Eur J Clin Pharmacol . 1986;30:225–230
  21. Czock D , Keller F , Rasche FM , Haussler U . Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids . Clin Pharmacokinet . 2005;44:61–98
  22. Luo JC, Chi CW, Lin HY, Chang FY, Lu CL, Chen CY, et al. Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation . J Pharmacol Exp Ther . 2007;320:687–694

PII: S1726-4901(09)70419-8

doi: 10.1016/S1726-4901(09)70419-8

Journal of the Chinese Medical Association
Volume 72, Issue 10 , Pages 509-514 , October 2009