Journal of the Chinese Medical Association
Volume 70, Issue 6 , Pages 245-248, June 2007

Effect of a Selective Nonsteroidal Anti-inflammatory Drug, Celecoxib, on the Reproductive Function of Female Mice

  • Peng-Hui Wang

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Peng-Hui Wang, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
    • ,
  • Huann-Cheng Horng

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Yi-Jen Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shie-Liang Hsieh

      Affiliations

    • Department of Microbiology and Immunology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Immunology Research Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Genomics Research Center, Academia Sinica, Taipei, Taiwan, R.O.C.
    • ,
  • Hsiang-Tai Chao

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Chiou-Chung Yuan

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Received 14 June 2006; accepted 16 May 2007.

Article Outline

Background

The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice.

Methods

Twenty-four female mice, 25 days of age, were given a selective COX-2 inhibitor: 3mg/kg celecoxib (n=8), 5mg/kg celecoxib (n = 8), or placebo (n=8) in a random fashion. Eight female mice, 10-11 weeks old, given 3mg/kg celecoxib (n = 4) or placebo (n =4) were subjected to continuous mating studies.

Results

Results from the 24 mice (n = 8 for each group) showed that oocyte number was not significantly different between female mice treated with either 3mg/kg or 5mg/kg celecoxib and placebo (21.4 ±2.5, 21.5±3.3, 23.3 ±3.8, respectively). From the continuous mating study, the litter size of female mice treated with celecoxib was not significantly different (8.2 ±1.3 pups/litter) compared to those treated with placebo (8.3 ±1.2 pups/litter). In addition, female mice treated with celecoxib had an average of 2.8±0.5 litters in a 12-week period, which was similar to female mice treated with placebo (3.0 ±0.8 litters/female).

Conclusion

This study suggests that use of low-dose (≤5mg/kg) selective COX-2 inhibitor in a mouse model does not significantly impair the female reproductive function.

Key Words:  cyclooxygenase-2 (COX-2) inhibitor , female , reproductive function , selective nonsteroidal anti-inflammatory drug

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PII: S1726-4901(09)70367-3

doi:10.1016/S1726-4901(09)70367-3

Journal of the Chinese Medical Association
Volume 70, Issue 6 , Pages 245-248, June 2007

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