Journal of the Chinese Medical Association
Volume 70, Issue 4 , Pages 176-179, April 2007

Acute Pancreatitis Associated with Ifosfamide

  • Miao-Chiu Hung

      Affiliations

    • Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
  • ,
  • Giun-Yi Hung

      Affiliations

    • Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Giun-Yi Hung, Department of Pediatrics, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
  • ,
  • Pei-Chin Lin

      Affiliations

    • Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • ,
  • Chui-Mei Tiu

      Affiliations

    • Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
  • ,
  • Yi-Ching Tien

      Affiliations

    • Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.

Received 8 June 2006; accepted 31 January 2007.

Article Outline

Acute pancreatitis is a rare complication during chemotherapy for pediatric patients with solid tumors. We report a 9-year-old boy with osteosarcoma who experienced 2 episodes of pancreatitis 1 day and 48 days after infusion of ifosfamide (IFOS), respectively. From a MEDLINE search, this is the 3rd reported case and 2nd reported pediatric case of IFOS-induced pancreatitis, and only this case experienced late-onset pancreatitis.

Key Words:  chemotherapy , ifosfamide , pancreatitis

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Manfred H , Lester R . Drug-induced pancreatitis: lessons in data mining . Br J Clin Pharmacol . 2004;58:560–562
  2. Carli M , Passone E , Perilongo G , Bisogno G . Ifosfamide in pediatric solid tumor . Oncology . 2003;65:99–104
  3. Klastersky J . Side effects of ifosfamide . Oncology . 2003;65:7–10
  4. Garcia AA . Ifosfamide-induced Fanconi syndrome . Ann Pharmacother . 1995;29:590–591
  5. Izraeli S , Adamson PC , Blaney SM , Balis FM . Acute pancreatitis after ifosfamide therapy . Cancer . 1994;74:1627–1628
  6. Gerson R , Serrano A , Villalobos A , Sternbach GL , Varon J . Acute pancreatitis secondary to ifosfamide . J Emerg Med . 1997;15:645–647
  7. Alberti-Flor JJ . Pancreatitis associated with ondansetron . J Natl Cancer Inst . 1995;87:689–690
  8. Feldman M . Acute pancreatitis . In:  Sleisenger MH ,  Fordtran JS ,  Feldman M editor. Sleisenger and Fortdtran's Gastrointestinal and Liver Disease . 7th edition. Philadelphia: Saunders; 2002;p. 919

PII: S1726-4901(09)70353-3

doi:10.1016/S1726-4901(09)70353-3

Journal of the Chinese Medical Association
Volume 70, Issue 4 , Pages 176-179, April 2007