Journal of the Chinese Medical Association
Volume 70, Issue 3 , Pages 121-125, March 2007

Helicobacter pylori-negative Low-grade Extranodal B-cell Primary Gastric Mucosa-associated Lymphoid Tissue Lymphoma

  • Ying-Ying Yang

      Affiliations

    • Division of General Medicine, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Su-Shun Lo

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Fen Yau Li

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Han-Chieh Lin

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Division of Gastroenterology, Department of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Han-Chieh Lin, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
    • ,
  • Fa-Yauh Lee

      Affiliations

    • Division of General Medicine, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Full-Young Chang

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Division of Gastroenterology, Department of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shou-Dong Lee

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Division of Gastroenterology, Department of Medicine, Taipei, Taiwan, R.O.C.

Received 5 June 2006; accepted 17 November 2006.

Article Outline

Helicobacter pylori-negative primary mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach-a primary gastric lymphoma (PGL)-is not very common. Herein, we report a 77-year-old man with the chief complaint of intermittent epigastric pain. Initial upper gastrointestinal (UGI) endoscopy showed multiple irregular ulcers (GUs) over the antrum with poor distention of the stomach, and gastric adenocarcinoma (Borrmann type IV, linitis plastica) was suspected. But the biopsy specimens of the GUs showed chronic inflammation without malignant change or H. pylori infection. Nevertheless, delayed healing of the GUs, specific endoscopic findings and enlarged paragastric lymph nodes on computed tomography of the abdomen alerted us to the possibility of PGL. After repeat UGI endoscopies, the patient was finally diagnosed with extranodal B-cell PGL. The patient received radical subtotal gastrectomy and Billroth II operation; the surgical margins were free of tumor cells. The patient was followed up in the outpatient department for 20 months, and his postoperative condition was good.

Key Words:  enlarged paragastric lymph nodes , Helicobacter pylori , primary mucosa-associated lymphoid tissue gastric lymphoma

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PII: S1726-4901(09)70342-9

doi:10.1016/S1726-4901(09)70342-9

Journal of the Chinese Medical Association
Volume 70, Issue 3 , Pages 121-125, March 2007

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