Journal of the Chinese Medical Association
Volume 70, Issue 1 , Pages 24-29, January 2007

Toward a Better Understanding of Sinonasal Mucosal Melanoma: Clinical Review of 23 Cases

  • Yen-Fu Cheng

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Chien-Chung Lai

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Ching-Yin Ho

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Chih-Hung Shu

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Ching-Zong Lin

      Affiliations

    • Department of Otorhinolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Ching-Zong Lin, Department of Otorhinolaryngology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.

Received 12 May 2006; received in revised form 7 December 2006

Article Outline

Background

Primary sinonasal mucosal melanoma is a rare disease, occurring far less often than cutaneous lesions. The objective of this study was to review the records of patients diagnosed with primary sinonasal mucosal melanoma.

Methods

We performed a retrospective review of the medical records of 23 patients with sinonasal mucosal melanoma who were treated at Taipei Veterans General Hospital between 1982 and 2002.

Results

Sixteen of the 23 patients were male and 7 were female; their mean age was 68.2 years (range, 39-87 years). At diagnosis, the melanoma was limited to lesions located in the sinonasal area in 20 patients, and had spread in 3 patients. Local recurrence developed in 9 patients, neck metastasis in 5, and distant metastasis in 19. The 5-year disease-specific survival and local control rates were 22.26% and 52.30%, respectively.

Conclusion

In our experience, primary sinonasal mucosa melanoma is prone to spread from the site of origin. The major obstacle in improving overall survival is achieving systemic control.

Key Words:  melanoma , nasal mucosa , nasal neoplasm , paranasal sinus neoplasm

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PII: S1726-4901(09)70296-5

doi:10.1016/S1726-4901(09)70296-5

Journal of the Chinese Medical Association
Volume 70, Issue 1 , Pages 24-29, January 2007

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