Journal of the Chinese Medical Association
Volume 70, Issue 1 , Pages 11-15, January 2007

Role of p21WAF1 and p27KIP1 in Predicting Biochemical Recurrence for Organ-confined Prostate Adenocarcinoma

  • Tony Tong-Lin Wu

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Tony T.L. Wu, Division of Urology, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, R.O.C.
    • ,
  • Jyh-Seng Wang

      Affiliations

    • Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Bang-Ping Jiaan

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • ,
  • Chia-Cheng Yu

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • ,
  • Jeng-Yu Tsai

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • ,
  • Jen-Tai Lin

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • ,
  • Jong-Khing Huang

      Affiliations

    • Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Received 27 June 2005; received in revised form 4 December 2006

Article Outline

Background

Both p21WAF1 and p27KIP1 have been reported as prognostic markers predicting biochemical failure for prostate cancers. We examined the expression and prognostic significance of p21WAF1 and p27KIP1 in organ-confined (pT2) prostate cancer patients.

Methods

The medical records of 53 pT2 prostate adenocarcinomas were analyzed retrospectively. Radical prostatectomy specimens were stained using anti-p21WAF1 and anti-p27KIP1 antibodies. Biochemical relapse was defined as 2 consecutive elevations in serum prostate specific antigen (PSA) level > 0.2 ng/mL with an interval of more than 3 months. The prognostic significance of p21WAF1 and p27KIP1 expression was assessed.

Results

p21WAF1 immunoreactivity was found in 19 patients (35.8%). Twenty-nine tumors (54.7%) had decreased p27KIP1 expression. Both markers were not associated with Gleason scores (p = 1.00 for both). At a median follow-up of 49 months, 15 patients (28.3%) experienced biochemical recurrence. Both p21 and p27 had no prognostic significance in log-rank test (p = 0.98 and p = 0.64, respectively).

Conclusion

p21WAF1 and p27KIP1 expression have no role in predicting biochemical relapse for stage pT2 prostate cancers.

Key Words:  p21 , p27 , prognosis , prostate neoplasms

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PII: S1726-4901(09)70294-1

doi:10.1016/S1726-4901(09)70294-1

Journal of the Chinese Medical Association
Volume 70, Issue 1 , Pages 11-15, January 2007

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