Role of p21WAF1 and p27KIP1 in Predicting Biochemical Recurrence for Organ-confined Prostate Adenocarcinoma

Wu, Tony Tong-Lin; Wang, Jyh-Seng; Jiaan, Bang-Ping; Yu, Chia-Cheng; Tsai, Jeng-Yu; Lin, Jen-Tai; Huang, Jong-Khing

doi:10.1016/S1726-4901(09)70294-1

« Previous Next »Journal of the Chinese Medical Association
Volume 70, Issue 1 , Pages 11-15, January 2007

Role of p21^WAF1 and p27^KIP1 in Predicting Biochemical Recurrence for Organ-confined Prostate Adenocarcinoma

Tony Tong-Lin Wu
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
- National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
- Correspondence to: Dr Tony T.L. Wu, Division of Urology, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1^st Road, Kaohsiung 813, Taiwan, R.O.C.
Jyh-Seng Wang
- Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
- National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
Bang-Ping Jiaan
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
Chia-Cheng Yu
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
Jeng-Yu Tsai
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
Jen-Tai Lin
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
Jong-Khing Huang
- Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
- National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Received 27 June 2005; received in revised form 4 December 2006

Background

Both p21^WAF1 and p27^KIP1 have been reported as prognostic markers predicting biochemical failure for prostate cancers. We examined the expression and prognostic significance of p21^WAF1 and p27^KIP1 in organ-confined (pT2) prostate cancer patients.

Methods

The medical records of 53 pT2 prostate adenocarcinomas were analyzed retrospectively. Radical prostatectomy specimens were stained using anti-p21^WAF1 and anti-p27^KIP1 antibodies. Biochemical relapse was defined as 2 consecutive elevations in serum prostate specific antigen (PSA) level > 0.2 ng/mL with an interval of more than 3 months. The prognostic significance of p21^WAF1 and p27^KIP1 expression was assessed.

Results

p21^WAF1 immunoreactivity was found in 19 patients (35.8%). Twenty-nine tumors (54.7%) had decreased p27^KIP1 expression. Both markers were not associated with Gleason scores (p = 1.00 for both). At a median follow-up of 49 months, 15 patients (28.3%) experienced biochemical recurrence. Both p21 and p27 had no prognostic significance in log-rank test (p = 0.98 and p = 0.64, respectively).