Journal of the Chinese Medical Association
Volume 69, Issue 9 , Pages 404-408, September 2006

Characteristics Predicting Dyslipidemia in Drug-naïve Type 2 Diabetes Patients

  • Shi-Dou Lin

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taichung, Taiwan, R.O.C.
    • ,
  • Shih-Te Tu

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taichung, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Shih-Te Tu, Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, 135, Nan-Shiao Street, Changhua 500, Taiwan, R.O.C.
    • ,
  • Shang-Ren Hsu

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taichung, Taiwan, R.O.C.
    • ,
  • Kwo-Chuan Lin

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taichung, Taiwan, R.O.C.
    • ,
  • Wayne Huey-Herng Sheu

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taichung, Taiwan, R.O.C.
    • Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

Received 1 December 2005; accepted 3 July 2006.

Background

Plasma lipid concentrations are related to a variety of attributes in obese subjects, but these relationships have not been extensively examined in type 2 diabetes patients.

Methods

A cross-sectional survey was conducted on type 2 diabetes patients who had never been treated with antihy-pertensives, lipid-lowering agents, and oral antidiabetic drugs other than sulfonylureas. Statistical analysis was performed to search for the correlation between lipid profiles and various parameters.

Results

Among diabetic men, the plasma triglyceride (TG) level was positively correlated with the waist-to-hip ratio (WHR) and alcohol consumption, whereas high-density lipoprotein cholesterol (HDL-C) was negatively correlated with age and body mass index (BMI). Obese persons and alcohol drinkers were more likely to need pharmacologic treatment for dyslipidemia. Among diabetic women, the plasma TG level was positively correlated with WHR and the duration of diabetes since diagnosis, while HDL-C was negatively correlated with WHR and BMI. The necessity of treatment for dyslipidemia increased with the duration of diabetes.

Conclusion

We recommend a more intensive monitoring of lipid levels in drug-naïve diabetic patients who possess the characteristics of alcohol consumption or older age (men), long duration of diabetes (women), and higher BMI or WHR (both genders).

Key Words:  drug-naïve , dyslipidemia , predictor , type 2 diabetes mellitus

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PII: S1726-4901(09)70282-5

doi:10.1016/S1726-4901(09)70282-5

Journal of the Chinese Medical Association
Volume 69, Issue 9 , Pages 404-408, September 2006

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