Journal of the Chinese Medical Association
Volume 69, Issue 8 , Pages 383-386, August 2006

Asymmetric Cerebral Lesion Pattern in X-linked Adrenoleukodystrophy

  • Shuang Wang

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Shuang Wang, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, Hangzhou 310009, China.
    • ,
  • Ji-Min Wu
    • ,
  • Yuan-Shen Cheng

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.

Received 17 May 2005; accepted 21 April 2006.

Article Outline

X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by peroxisomal dysfunction. X-ALD usually involves the cerebral white matter in an approximately symmetric way. We report a 10-year-old boy with the cerebral form of X-ALD who presented with cognitive impairment and left spastic hemiparesis. Brain magnetic resonance imaging (MRI) showed asymmetric lesions, and the lesions in the right hemisphere were predominant. In the late stage of the disease, bilateral limbs were involved. The cerebral lesions enlarged and appeared approximately symmetric on MRI. The purpose of our report is to highlight asymmetric demyelination in initial presentation of X-ALD.

Key Words:  adrenoleukodystrophy , hemiparesis , magnetic resonance imaging

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References 

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PII: S1726-4901(09)70277-1

doi:10.1016/S1726-4901(09)70277-1

Journal of the Chinese Medical Association
Volume 69, Issue 8 , Pages 383-386, August 2006

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