Journal of the Chinese Medical Association
Volume 69, Issue 6 , Pages 278-281 , June 2006

Invasive Pulmonary Aspergillosis with Cerebral Abscess in a Patient with Idiopathic Thrombocytopenic Purpura

  • Hung-Chin Tsai

      Affiliations

    • Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan, R.O.C.
    • ,
  • Susan Shin-Jung Lee

      Affiliations

    • Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shue-Ren Wann

      Affiliations

    • Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Yao-Shen Chen

      Affiliations

    • Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jyh-Seng Wang

      Affiliations

    • Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • ,
  • Yung-Ching Liu

      Affiliations

    • Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr. Yung-Ching Liu, Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, R.O.C.

Received 30 September 2005 ,Accepted 6 February 2006.

References 

  1. DeLone DR, Goldstein RA, Petermann G, Salamat MS, Miles JM, Knechtle SJ, et al. Disseminated aspergillosis involving the brain: distribution and imaging characteristics . AJNR Am J Neuroradiol . 1999;20:1597–1604
  2. Apostolidis J, Tsandekidi M, Kousiafes D, Pagoni M, Mitsouli C, Karmiris T, et al  Short-course corticosteroid-induced pulmonary and apparent cerebral aspergillosis in a patient with idiopathic thrombocytopenic purpura . Blood . 2001;98:2875–2877
  3. Buchheidt D , Hummel M , Diehl S , Hehlmann R . Fatal cerebral involvement in systemic aspergillosis: a rare complication of steroid-treated autoimmune bicytopenia . Eur J Haematol . 2004;72:375–376
  4. Lastours V , Lefort A , Zappa M , Dufour V , Belmatoug N , Fantin B . Two cases of cerebral aspergillosis successfully treated with voriconazole . Eur J Clin Microbiol Infect Dis . 2003;22:297–299
  5. Denning DW . Therapeutic outcome in invasive aspergillosis . Clin Infect Dis . 1996;23:608–615
  6. Darras-Joly C , Veber B , Bedos JP , Gachot B , Regnier B , Wolff M . Nosocomial cerebral aspergillosis: a report of 3 cases . Scand J Infect Dis . 1996;28:317–319
  7. Gerson SL , Talbot GH , Hurwitz S , Strom BL , Lusk EJ , Cassileth PA . Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia . Ann Intern Med . 1984;100:345–351
  8. Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, et al. Fungal infections in chronic granulomatous disease: the importance of the phagocyte in defense against fungi . Am J Med . 1981;71:59–66
  9. Morrison VA , Haaeke RJ , Weisdorf DJ . The spectrum of non-Candida fungal infections following bone marrow transplantation . Medicine (Baltimore) . 1993;72:78–89
  10. Wald A , Leisenring W , van Burik JA , Bowden RA . Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation . J Infect Dis . 1997;175:1459–1466
  11. Hibberd PL , Rubin RH . Clinical aspects of fungal infection in organ transplant recipients . Clin Infect Dis . 1994;19:33–40
  12. Denning DW , Follansbee SE , Scolaro M , Norris S , Edelstein H , Stevens DA . Pulmonary aspergillosis in the acquired immunodeficiency syndrome . N Engl J Med . 1991;324:654–662
  13. Guermazi A , Gluckman E , Tabti B , Miaux Y . Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview . Eur Radiol . 2003;13:377–388
  14. Kuhlman JE , Fishman EK , Burch PA , Karp JE , Zerhouni EA , Siegelman SS . Invasive pulmonary aspergillosis in acute leukemia: the contribution of CT to early diagnosis and aggressive management . Chest . 1987;92:95–99
  15. Curtis AM , Smith GJ , Ravin CE . Air crescent sign of invasive aspergillosis . Radiology . 1979;133:17–21
  16. Gefter WB , Albelda SM , Talbot GH , Gerson SL , Cassileth PA , Miller WT . Invasive pulmonary aspergillosis and acute leukemia: limitations in the diagnostic utility of the air crescent sign . Radiology . 1985;157:605–610
  17. Rogers TR , Haynes KA , Barnes RA . Value of antigen detection in predicting invasive pulmonary aspergillosis . Lancet . 1990;336:1210–1213
  18. Stevens DA, Kan VL, Judson MA, Morrison VA, Dummer S, Denning DW, et al  Practice guidelines for diseases caused by Aspergillus . Clin Infect Dis . 2000;30:696–709
  19. Johnson MD , MacDougall C , Ostrosky-Zeichner L , Perfect JR , Rex JH . Combination antifungal therapy . Antimicrob Agents Chemother . 2004;48:693–715
  20. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, et al  Voriconazole versus am-photericin B for primary therapy of invasive aspergillosis . N Engl J Med . 2002;347:408–415
  21. Lutsar I , Roffey S , Troke P . Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients . Clin Infect Dis . 2003;37:728–732
  22. Schwartz S , Milatovic D , Thiel E . Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemia . Br J Haematol . 1997;97:663–665

PII: S1726-4901(09)70257-6

doi: 10.1016/S1726-4901(09)70257-6

Journal of the Chinese Medical Association
Volume 69, Issue 6 , Pages 278-281 , June 2006

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