Journal of the Chinese Medical Association
Volume 69, Issue 6 , Pages 248-253 , June 2006

Association of Insulin Resistance and Hematologic Parameters: Study of a Middle-aged and Elderly Chinese Population in Taiwan

  • Liang-Kung Chen

      Affiliations

    • Department of Family Medicine Taipei, Taiwan, R.O.C.
    • Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Ming-Hsien Lin

      Affiliations

    • Department of Family Medicine Taipei, Taiwan, R.O.C.
    • Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Zhi-Jun Chen

      Affiliations

    • Department of Management, Ming Chuan University, Taipei, Taiwan, R.O.C.
    • ,
  • Shinn-Jang Hwang

      Affiliations

    • Department of Family Medicine Taipei, Taiwan, R.O.C.
    • Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Professor Shinn-Jang Hwang, Department of Family Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C.
    • ,
  • Shu-Ti Chiou

      Affiliations

    • National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Received 15 July 2005 ,Accepted 21 April 2006.

References 

  1. Reaven GM . Banting lecture 1988. Role of insulin resistance in human diseases . Diabetes . 1988;37:1595–1607
  2. Granberry MC , Fonseca VA . Insulin resistance syndrome: options for treatment . South Med J . 1999;92:2–15
  3. Opara JU , Levine JH . The deadly quartet- the insulin resistance syndrome . South Med J . 1997;90:1162–1168
  4. Gousseva N , Kugathasan K , Chesterman CN , Khachigian LM . Early growth response factor-I mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury . J Cell Biochem . 2001;81:523–534
  5. Despres JP, Lamarche B, Mauriege P, Cantin B, Dangenais GR, Moorjani S, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease . N Engl J Med . 1996;334:952–957
  6. Wisse BE . The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity . J Am Soc Nephrol . 2004;15:2792–2800
  7. Pickup JC , Mattock MB , Chusney GD , Burt D . NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X . Diabetologia . 1997;40:1286–1292
  8. Nakanishi N , Yoshida Y , Matsuo K , Suzuki K , Tatara K . White blood cell count and the risk of impaired fasting glucose or type II diabetes in middle-aged Japanese men . Diabetologia . 2002;45:42–48
  9. Barbieri M, Ragno E, Benvenuti E, Zito GA, Corsi A, Ferrucci L, et al. New aspects of insulin resistance syndrome: impact on haematological parameters . Diabetologia . 2001;44:1232–1237
  10. Grundy SM . Hypertriglyceridemia, insulin resistance, and the metabolic syndrome . Am J Cardiol . 1999;83:25–29
  11. Haffner SM , Valdez RA , Hazuda HP , Mitchell BD , Morales PA , Stern MP . Prospective analysis of the insulin resistance syndrome (syndrome X) . Diabetes . 1992;41:715–722
  12. Friedman GD , Teskawa I , Grimm RH , Manolio T , Shannon SG , Sidney S . The leukocyte count: correlates and relationship to coronary risks factors: the CARDIA study . Int J Epidemiol . 1990;19:889–893
  13. Nieto FJ , Szaklo M , Folsom AR , Rock R , Mercuri M . Leukocyte count in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study . Am J Epidemiol . 1992;136:527–537
  14. Shimakawa T , Bild DE . Relationship between hemoglobin and cardiovascular risk factors in young adults . J Clin Epidemiol . 1993;46:1257–1266
  15. Matthews DR , Hosker JP , Rudenski AS , Naylor BA , Treacher DF , Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man . Diabetologia . 1985;28:412–419
  16. Katsuki A, Sumida Y, Gabazza EC, Murashima S, Furuta M, Araki-Sasaki R, et al  Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes . Diabetes Care . 2001;24:362–365
  17. McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, Temple LA, et al. Diagnosing insulin resistance in the general population . Diabetes Care . 2001;24:460–464
  18. Chen LK , Lin MH , Chen ZJ , Hwang SJ , Chiou ST . Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese . Diabetes Res Clin Pract . 2006;71:170–176
  19. World Health Organization  . The Asia-Pacific Perspective: Redefining Obesity and Its Treatment . Geneva: WHO; 2000;
  20. The Expert Committee of the Diagnosis and Classification of Diabetes Mellitus  . Report of the expert committee on the diagnosis and classification of diabetes mellitus . Diabetes Care . 1997;20:1183–1197
  21. Virkamaki A , Ueki K , Khan CR . Protein-protein interaction in insulin signaling and the molecular mechanism of insulin resistance . J Clin Invest . 1999;103:931–943
  22. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, et al  Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo . J Clin Endocrinol Metab . 1997;82:41196–41200
  23. Campos SP , Baumann H . Insulin is a prominent modulator of the cytokine-stimulated expression of acute-phase plasma protein genes . Mol Cell Biol . 1992;12:1789–1797
  24. Ernst E , Hammerschmidt DE , Bagge U , Matrai A , Dormandy JA . Leukocytes and the risk of ischemic diseases . JAMA . 1987;257:2318–2324
  25. Aoki I , Taniyama M , Toyama K , Homori M , Ishikawa K . Stimulatory effect of human insulin on erythroid progenitors (CFU-E and BFU-E) in human CD34+ separated bone marrow cells and the relationship between insulin and erythropoietin . Stem Cell . 1994;12:329–338
  26. Perrine SP , Greene MF , Lee PD , Cohen RA , Faller DV . Insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia . Br J Haematol . 1986;64:503–511
  27. Wang YY , Lin SY , Liu PH , Cheung BM , Lai WA . Association with hematological parameters and metabolic syndrome components in a Chinese population . J Diabetes Complication . 2004;18:322–327
  28. Steinberg HO , Brechtel G , Johnson A , Fineberg N , Baron AD . Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release . J Clin Invest . 1994;94:1172–1179
  29. Trovati M, Mularoni EM, Burzacca S, Ponziani MC, Massucco P, Matiello L, et al  Impaired insulin induced platelet antiaggregating effect in obesity and in obese NIDDM patients . Diabetes . 1995;44:1318–1322
  30. Trovati M , Anfossi G , Cavalot F , Massucco P , Mularoni E , Emanuelli G . Insulin directly reduces platelet sensitivity to aggregating agents: studies in vitro and in vivo . Diabetes . 1988;37:780–786
  31. Vinik AI , Erbas T , Park TS , Nolan R , Pittenger GL . Platelet dysfunction in type 2 diabetes . Diabetes Care . 2001;24:1476–1485
  32. Taniguchi A, Fukushima M, Seino Y, Sakai M, Yoshii S, Nagasaka S, et al  Platelet count is independently associated with insulin resistance in nonobese Japanese type 2 diabetic patients . Metabolism . 2003;52:1246–1249

PII: S1726-4901(09)70251-5

doi: 10.1016/S1726-4901(09)70251-5

Journal of the Chinese Medical Association
Volume 69, Issue 6 , Pages 248-253 , June 2006

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