Journal of the Chinese Medical Association
Volume 69, Issue 4 , Pages 166-168, April 2006

Nephrogenic Adenoma of the Urinary Bladder: Clinical Experience and Review of the Literature

  • Chuan-Shu Chen
    • ,
  • Chen-Li Cheng

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr. Chen-Li Cheng, Division of Urology, Department of Surgery, Taichung Veterans General Hospital, 160, Section 3, Chung-Kun Road, Taichung 407, Taiwan, R.O.C.

Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

Received 5 September 2005; accepted 27 February 2006.

Article Outline

Background

Nephrogenic adenoma (NA) is a rare disease of the urinary tract. We report our clinical experience with this disease in the urinary bladder and review the literature.

Methods

Between April 1994 and July 2004, 8 patients were diagnosed with NA of the urinary bladder: 3 men and 5 women, aged 23–77 years (mean 49.6). Multiple predisposing factors were analyzed. The mean follow-up time was 56 months.

Results

NA was not associated with transitional cell carcinoma in our series. All patients had recurrent urinary tract infection. Urinary tuberculosis was diagnosed in 2 patients. Two patients had undergone previous open urosurgery, and 4 patients had received previous endourologic management. A history of urolithiasis was found in 1 patient. Previous long-term urinary catheterization was noted in 3 patients. Two patients had received pelvic radiation therapy for cervical cancer. Urinary frequency and microscopic hematuria were found in all patients. All nephrogenic adenomas were treated with transurethral resection. Recurrent nephrogenic adenomas were diagnosed in 3 patients (median time to disease relapse, 7 months). Recurrent tumors were also treated with the endourologic method.

Conclusion

NA is an uncommon benign metaplastic lesion occurring in the urothelium. Transurethral resection of NA provides a definite diagnosis and relief of symptoms. The recurrence rate of NA is relatively high, so careful and long-term follow-up is necessary.

Key Words:  nephrogenic adenoma , urinary bladder , urothelium

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Davis TA . Hamartoma of the urinary bladder . Northwest Med . 1949;48:182–185
  2. Friedman NB , Kuhlenbeck H . Adenomatoid tumor of the bladder reproducing renal structures (nephrogenic adenoma) . J Urol . 1950;64:657–670
  3. Gilcrease MZ , Delgado R , Vuitch F . Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison . Hum Pathol . 1998;29:1451–1456
  4. Kunze E , Fischer G , Dembowski J . Tubulo-papillary adenoma (so-called nephrogenic adenoma) arising in the renal pelvis: report of a case with a critical consideration of histogenesis and terminology . Pathol Res Pract . 1993;189:217–225
  5. Olivia E , Young RH . Nephrogenic adenoma of the urinary tract: a review of the microscopic appearance of 80 cases with emphasis on unusual features . Mod Pathol . 1995;8:722–730
  6. Stilmant MM , Siroky MB . Nephrogenic adenoma associated with intravesical Bacillus Calmette-Guérin treatment: a report of 2 cases . J Urol . 1986;135:359–361
  7. Banyai-Falger S , Maier U , Susani M . High incidence of nephrogenic adenoma of the bladder after renal transplantation . Transplantation . 1998;65:511–514
  8. Porcaro AB , D'Amico A , Ficarra V . Nephrogenic adenoma of the urinary bladder: our experience and review of the literature . Urol Int . 2001;66:152–155
  9. Peeker R , Aldenborg F , Fall M . Nephrogenic adenoma: a study with special reference to clinical presentation . Br J Urol . 1997;80:539–542
  10. Kaswick JA , Waisman J , Goodwin WE . Nephrogenic metaplasia (adenomatoid tumors) of bladder . Urology . 1976;8:283–286
  11. Husain AN , Armin AR , Schuster GA . Nephrogenic metaplasia of urinary tract in children: report of three cases and review of the literature . Pediatr Pathol . 1988;8:293–300
  12. Navarre RJ , Loening SA , Platz C . Nephrogenic adenoma: a report of 9 cases and review of the literature . J Urol . 1982;127:775–779

PII: S1726-4901(09)70199-6

doi:10.1016/S1726-4901(09)70199-6

Journal of the Chinese Medical Association
Volume 69, Issue 4 , Pages 166-168, April 2006

Article Tools