Journal of the Chinese Medical Association
Volume 71, Issue 10 , Pages 523-527, October 2008

Nodular Regenerative Hyperplasia of the Liver

  • Huay-Min Wang

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Gin-Ho Lo

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Gin-Ho Lo, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, R.O.C.
    • ,
  • Ping-I Hsu

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Chiun-Ku Lin

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Hoi-Hung Chan

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Wen-Chi Chen

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Kwok-Hung Lai

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Taiwan, R.O.C.
    • ,
  • Being-Whey Wang

      Affiliations

    • Division of General Surgery, Department of Surgery, Taiwan, R.O.C.
    • ,
  • Shong-Ling Lin

      Affiliations

    • Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.

Received 15 January 2008; accepted 8 May 2008.

Article Outline

Nodular regenerative hyperplasia (NRH), characterized by diffuse hepatic micronodular transformation in groups without fibrous septa between the nodules, is a rare benign liver lesion that has many synonyms in previous literature. Pathologic evaluation is the mainstay of accurate diagnosis. Treatment is focused on its underlying conditions and complications of portal hypertension. A 39-year-old man visited our hospital due to right upper quadrant pain and a palpable liver mass. Magnetic resonance examination revealed a slightly hyperintense tumor on T2-weighted images, and focal nodular hyperplasia was diagnosed by the radiologists. Atypical radiologic findings could not yield an accurate diagnosis. Surgical intervention was therefore performed. Pathologic examination of the resected liver tumor confirmed the diagnosis of NRH. We conclude that NRH should be included in the differential diagnosis of benign liver tumor.

Key Words:  benign liver tumor , diagnosis , nodular regenerative hyperplasia

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PII: S1726-4901(08)70161-8

doi:10.1016/S1726-4901(08)70161-8

Journal of the Chinese Medical Association
Volume 71, Issue 10 , Pages 523-527, October 2008

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