Journal of the Chinese Medical Association
Volume 71, Issue 5 , Pages 267-269, May 2008

Potential Role of Intravenous Immunoglobulin in the Management of Peripartum Maternal Thrombocytopenia Due to Various Causes

  • Fu-Nan Cho

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Fu-Nan Cho, Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, R.O.C
    • ,
  • Cheng-Bin Liu

Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.

Received 7 March 2007; accepted 6 December 2007.

Article Outline

Severe maternal thrombocytopenia resulting in hemorrhage is often associated with high mortality. Three cases of severe maternal thrombocytopenia in association with heparin-induced thrombocytopenia (HIT), HELLP syndrome, and systemic lupus erythematosus (SLE) were successfully managed using intravenous immunoglobulin (IVIG). IVIG can reduce the severity of thrombocytopenia and hemolysis, stabilize lupus activity, prevent peripartum hemorrhage, and shorten hospitalization, but it may induce reversible interstitial nephritis and membranous glomerulonephritis. IVIG may be beneficial in the management of severe peripartum maternal thrombocytopenia in association with HIT, HELLP syndrome, and SLE. [J Chin Med Assoc 2008;71(5):267–269]

Key Words:  HELLP syndrome , heparin , intravenous immunoglobulin , systemic lupus erythematosus , thrombocytopenia

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PII: S1726-4901(08)70119-9

doi:10.1016/S1726-4901(08)70119-9

Journal of the Chinese Medical Association
Volume 71, Issue 5 , Pages 267-269, May 2008

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