Journal of the Chinese Medical Association
Volume 71, Issue 5 , Pages 247-253 , May 2008

Efficacy of a Very-low-dose Combination of Perindopril and Indapamide—Preterax Compared with Cilazapril Monotherapy in Patients with Inadequate Blood Pressure Control—A Randomized, Double-blind, Add-on Study

  • Shih-Hsien Sung

      Affiliations

    • Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Tao-Cheng Wu

      Affiliations

    • Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Shing-Jong Lin

      Affiliations

    • Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Jaw-Wen Chen

      Affiliations

    • Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Jaw-Wen Chen, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C

Received 20 July 2007 ,Accepted 20 March 2008.

References 

  1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al  The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report . JAMA . 2003;289:2560–2571
  2. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure . Arch Intern Med . 1997;157:2413–2446
  3. Colhoun HM , Dong W , Poulter NR . Blood pressure screening, management and control in England: results from the health survey for England 1994 . J Hypertens . 1998;16:747–752
  4. Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, et al  Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial–Blood Pressure Lowering Arm (ASCOTBPLA): a multicentre randomised controlled trial . Lancet . 2005;366:895–906
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  9. de Leeuw PW, Ruilope LM, Palmer CR, Brown MJ, Castaigne A, Mancia G, et al  Clinical significance of renal function in hypertensive patients at high risk: results from the INSIGHT trial . Arch Intern Med . 2004;164:2459–2464
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  11. PROGRESS Collaborative Group . Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack . Lancet . 2001;358:1033–1041
  12. Dahlof B, Gosse P, Gueret P, Dubourg O, de SG, Schmieder R, et al  Perindopril/indapamide combination more effective than enalapril in reducing blood pressure and left ventricular mass: the PICXEL study . J Hypertens . 2005;23:2063–2070
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  14. de Luca N, Mallion JM, O’Rourke MF, O’Brien E, Rahn KH, Trimarco B, et al  Regression of left ventricular mass in hypertensive patients treated with perindopril/indapamide as a first-line combination: the REASON echocardiography study . Am J Hypertens . 2004;17:660–667
  15. Asmar RG , London GM , O’Rourke ME , Safar ME . Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patients: a comparison with atenolol . Hypertension . 2001;38:922–926
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  17. Vasan RS, Larson MG, Leip EP, Evans JC, O’Donnell CJ, Kannel WB, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease . N Engl J Med . 2001;345:1291–1297
  18. Chanudet X , De CM . Antihypertensive efficacy and tolerability of low-dose perindopril/indapamide combination compared with losartan in the treatment of essential hypertension . Int J Clin Pract . 2001;55:233–239

PII: S1726-4901(08)70115-1

doi: 10.1016/S1726-4901(08)70115-1

Journal of the Chinese Medical Association
Volume 71, Issue 5 , Pages 247-253 , May 2008

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