Journal of the Chinese Medical Association
Volume 71, Issue 8 , Pages 416-420, August 2008

Acute Myeloid Leukemia Associated with Acute Myocardial Infarction and Dural Sinus Thrombosis: The Possible Role of Leukemia-related Hyperhomocysteinemia

  • Hung Chang

      Affiliations

    • Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taipei, and Chang Gung University School of Medicine, Taoyuan, Taiwan, R.O.C.
    • ,
  • Tung-Liang Lin

      Affiliations

    • Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taipei, and Chang Gung University School of Medicine, Taoyuan, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Tung-Liang Lin, Division of Hematology-Oncology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei 105, Taiwan, R.O.C.
    • ,
  • Wan-Jing Ho

      Affiliations

    • Department of Cardiology, Chang Gung Memorial Hospital, Taipei, and Chang Gung University School of Medicine, Taoyuan, Taiwan, R.O.C.
    • ,
  • Lung-An Hsu

      Affiliations

    • Department of Cardiology, Chang Gung Memorial Hospital, Taipei, and Chang Gung University School of Medicine, Taoyuan, Taiwan, R.O.C.

Received 17 September 2007; accepted 27 March 2008.

The association of acute myeloid leukemia (AML) and acute myocardial infarction (AMI) is rare. We encountered a 40-year-old female with inferior wall myocardial infarction that occurred simultaneously with the diagnosis of AML. She developed subsequent dural sinus thrombosis during chemotherapy for AML. The screen for thrombophilia revealed that she had hyperhomocysteinemia. In the English literature, only 4 cases have been reported previously. Remission induction was not affected by the occurrence of AMI, although anthracyclines were avoided in all cases. In the absence of conventional risk factors for coronary artery disease, AMI can be related to leukemia per se and the role of homocysteine is worth further investigation.

Key Words:  acute myeloid leukemia , acute myocardial infarction , dural sinus thrombosis , homocysteine , thrombophilia

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PII: S1726-4901(08)70093-5

doi:10.1016/S1726-4901(08)70093-5

Journal of the Chinese Medical Association
Volume 71, Issue 8 , Pages 416-420, August 2008

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