Journal of the Chinese Medical Association
Volume 71, Issue 8 , Pages 386-391 , August 2008

Luteal Support for IVF/ICSI Cycles with Crinone 8% (90 mg) Twice Daily Results in Higher Pregnancy Rates Than with Intramuscular Progesterone

  • Chi-Hong Ho

      Affiliations

    • Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Shee-Uan Chen

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Shee-Uan Chen, Department of Obstetrics and Gynecology, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei 100, Taiwan, R.O.C.
    • ,
  • Fu-Shiang Peng

      Affiliations

    • Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan, R.O.C.
    • ,
  • Chih-Yuan Chang

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, R.O.C.
    • ,
  • Yu-Shih Yang

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, R.O.C.

Received 23 January 2008 ,Accepted 27 June 2008.

References 

  1. Soliman S , Daya S , Collins J , Hughes EG . The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials . Fertil Steril . 1994;61:1068–1076
  2. Daya S , Gunby J . Luteal phase support in assisted reproduction cycles . Cochrane Database Syst Rev . 2004; CD004830
  3. Levine H . Luteal support in IVF using the novel vaginal progesterone gel Crinone 8%: results of an open-label trial in 1184 women from 16 US centers . Fertil Steril . 2000;74:836–837
  4. Penzias AS , Alper MM . Luteal support with vaginal micronized progesterone gel in assisted reproduction . Reprod Biomed Online . 2003;6:287–295
  5. Pritts EA , Atwood AK . Luteal phase support in infertility treatment: a meta-analysis of the randomized trials . Hum Reprod . 2002;17:2287–2299
  6. Penzias AS . Luteal phase support . Fertil Steril . 2002;77:318–323
  7. Arslan M , Bocca S , Arslan EO , Duran HE , Stadtmauer L , Oehninger S . Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation . J Assist Reprod Genet . 2007;24:111–117
  8. Choi BC , Polgar K , Xiao L , Hill JA . Progesterone inhibits in vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss . Hum Reprod . 2000;15(Suppl):46–59
  9. Chen CD , Wu MY , Chao KH , Chen SU , Ho HN , Yang YS . Serum estradiol level and oocyte number in predicting severe ovarian hyperstimulation syndrome . J Formos Med Assoc . 1997;96:829–834
  10. Bulletti C , De ZD , Flamigni C , Giacomucci E , Polli V , Bolelli G , et al.   Targeted drug delivery in gynaecology: the first uterine pass effect . Hum Reprod . 1997;12:1073–1079
  11. Cicinelli E , De ZD , Bulletti C , Matteo MG , Schonauer LM , Galantino P . Direct transport of progesterone from vagina to uterus . Obstet Gynecol . 2000;95:403–406
  12. Miles RA , Paulson RJ , Lobo RA , Press MF , Dahmoush L , Sauer MV . Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study . Fertil Steril . 1994;62:485–490
  13. Fanchin R , De ZD , Bergeron C , Righini C , Torrisi C , Frydman R . Transvaginal administration of progesterone . Obstet Gynecol . 1997;90:396–401
  14. Chantilis SJ , Zeitoun KM , Patel SI , Johns DA , Madziar VA , McIntire DD . Use of Crinone vaginal progesterone gel for luteal support in in vitro fertilization cycles . Fertil Steril . 1999;72:823–829
  15. Propst AM , Hill JA , Ginsburg ES , Hurwitz S , Politch J , Yanushpolsky EH . A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles . Fertil Steril . 2001;76:1144–1149
  16. Damario MA , Goudas VT , Session DR , Hammitt DG , Dumesic DA . Crinone 8% vaginal progesterone gel results in lower embryonic implantation efficiency after in vitro fertilization-embryo transfer . Fertil Steril . 1999;72:830–836
  17. Perino M , Brigandi FG , Abate FG , Costabile L , Balzano E , Abate A . Intramuscular versus vaginal progesterone in assisted reproduction: a comparative study . Clin Exp Obstet Gynecol . 1997;24:228–231
  18. Abate A , Perino M , Abate FG , Brigandi A , Costabile L , Manti F . Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study . Clin Exp Obstet Gynecol . 1999;26:203–206
  19. Pellicer A , Valbuena D , Cano F , Remohi J , Simon C . Lower implantation rates in high responders: evidence for an altered endocrine milieu during the preimplantation period . Fertil Steril . 1996;65:1190–1195
  20. Gibbons WE , Toner JP , Hamacher P , Kolm P . Experience with a novel vaginal progesterone preparation in a donor oocyte program . Fertil Steril . 1998;69:96–101
  21. Paulson RJ , Sauer MV , Lobo RA . Embryo implantation after human in vitro fertilization: importance of endometrial receptivity . Fertil Steril . 1990;53:870–874
  22. Simon C , Cano F , Valbuena D , Remohi J , Pellicer A . Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients . Hum Reprod . 1995;10:2432–2437
  23. Chen QJ, Sun XX, Li L, Gao XH, Wu Y, Gemzell-Danielsson K, et al. Effects of ovarian high response on implantation and pregnancy outcome during controlled ovarian hyperstimulation (with GnRH agonist and rFSH) . Acta Obstet Gynecol Scand . 2007;86:849–854
  24. Toner JP , Hassiakos DK , Muasher SJ , Hsiu JG , Jones HW . Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates . Ann NY Acad Sci . 1991;622:220–229
  25. Basir GS , Ws O , Ng EH , Ho PC . Morphometric analysis of peri-implantation endometrium in patients having excessively Comparing vaginal gel and intramuscular progesterone as luteal phase support in IVF/ICSI treatment high oestradiol concentrations after ovarian stimulation . Hum Reprod . 2001;16:435–440
  26. Ng EH , Chan CC , Tang OS , Yeung WS , Ho PC . Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders . Hum Reprod . 2004;19:924–931
  27. Makkar G , Ng EH , Yeung WS , Ho PC . Reduced expression of interleukin-11 and interleukin-6 in the periimplantation endometrium of excessive ovarian responders during in vitro fertilization treatment . J Clin Endocrinol Metab . 2006;91:3181–3188
  28. Wegmann TG , Lin H , Guilbert L , Mosmann TR . Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? . Immunol Today . 1993;14:353–356
  29. Hutchinson-Williams KA , DeCherney AH , Lavy G , Diamond MP , Naftolin F , Lunenfeld B . Luteal rescue in in vitro fertilizationembryo transfer . Fertil Steril . 1990;53:495–501
  30. de Ziegler D , Bouchard P . Understanding endometrial physiology and menstrual disorders in the 1990s . Curr Opin Obstet Gynecol . 1993;5:378–388
  31. Farhi J , Weissman A , Steinfeld Z , Shorer M , Nahum H , Levran D . Estradiol supplementation during the luteal phase may improve the pregnancy rate in patients undergoing in vitro fertilizationembryo transfer cycles . Fertil Steril . 2000;73:761–766
  32. Gorkemli H , Ak D , Akyurek C , Aktan M , Duman S . Comparison of pregnancy outcomes of progesterone or progesterone + estradiol for luteal phase support in ICSI-ET cycles . Gynecol Obstet Invest . 2004;58:140–144

PII: S1726-4901(08)70088-1

doi: 10.1016/S1726-4901(08)70088-1

Journal of the Chinese Medical Association
Volume 71, Issue 8 , Pages 386-391 , August 2008

Article Tools