Journal of the Chinese Medical Association
Volume 71, Issue 2 , Pages 86-91, February 2008

Second Primary Malignancies in Squamous Cell Carcinomas of the Tongue and Larynx: An Analysis of Incidence, Pattern, and Outcome

  • Yen-Bin Hsu

      Affiliations

    • Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, Buddhist Tzu Chi Xindian General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, Tzu Chi University, Hualien, Taiwan, R.O.C.
    • ,
  • Shyue-Yih Chang

      Affiliations

    • Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • ,
  • Ming-Chin Lan

      Affiliations

    • Department of Otolaryngology, Buddhist Tzu Chi Xindian General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, Tzu Chi University, Hualien, Taiwan, R.O.C.
    • ,
  • Jui-Lin Huang

      Affiliations

    • Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • ,
  • Shyh-Kuan Tai

      Affiliations

    • Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • ,
  • Pen-Yuan Chu

      Affiliations

    • Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    • Corresponding Author InformationCorrespondence to: Dr Pen-Yuan Chu, Department of Otolaryngology, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C

Received 31 October 2007; accepted 19 December 2007.

Article Outline

Background

Head and neck cancer patients have a higher risk of developing a second primary malignancy (SPM) than the general population. This study was conducted to identify the characteristics of SPM and its impact on survival in patients with squamous cell carcinoma of the tongue (TSCC) and larynx (LSCC).

Methods

A retrospective study was conducted of 538 patients who were treated by surgery primarily for TSCC (n = 146) and LSCC (n = 392) from 1990 to 2000. The incidence, site, and overall survival of SPMs were evaluated.

Results

Seventy-seven patients developed SPM during the follow-up period (median, 73 months), including 18 (12%) with TSCC and 59 (15%) with LSCC. Fifty-six percent of SPMs of the TSCC group appeared in the oral cavity. Among the SPMs of LSCC patients, 54% developed in the lung (31%) and larynx (24%). The 5-year overall survival after the diagnosis of SPM in the head and neck was 39%, compared to 29% for SPM in other areas (p = 0.010).

Conclusion

SPMs after treatment of TSCC and LSCC are similar in incidence but distinct in pattern. SPMs within the head and neck are associated with a better prognosis than those outside this area.

Key Words:  head and neck , laryngeal cancer , second primary tumor , tongue cancer

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PII: S1726-4901(08)70080-7

doi:10.1016/S1726-4901(08)70080-7

Journal of the Chinese Medical Association
Volume 71, Issue 2 , Pages 86-91, February 2008

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